Prmt1 CLIA Kit for Mouse(Mus musculus) | EIAab.comPrmt1 CLIA Kit for Mouse(Mus musculus)

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Prmt1 (Gene name),

Protein arginine N-methyltransferase 1 (Protein name ), ANM1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Prmt1(Hrmt1l2;Mrmt1);

Protein name:

Protein arginine N-methyltransferase 1;

Alternative:

2.1.1.125;Histone-arginine N-methyltransferase PRMT1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1.

Function:

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.

Subcellular Location:

Nucleus Cytoplasm cytosol

Protein Attributes:

Sequence length:

371

Sequence:

50:

100:

150:

200:

250:

300:

350:

371:

IDLDFKGQLC | ELSCSTDYRM | R

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF13847

KEGG:

mmu:15469

SMR:

Q9JIF0

UniGene:

Mm.27545

String:

Q9JIF0

Uniprot:

Q9JIF0

FOR

ELISA Kit for Mouse Protein arginine N-methyltransferase 1

Cat.:

E15261h

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Protein arginine N-methyltransferase 1

Cat.:

E15261r

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Protein arginine N-methyltransferase 1

Cat.:

E15261m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Protein arginine N-methyltransferase 1

Cat.:

U15261r

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Protein arginine N-methyltransferase 1

Cat.:

U15261m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Protein arginine N-methyltransferase 1

Cat.:

U15261h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Protein arginine N-methyltransferase 1

Cat.:

P15261Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Protein arginine N-methyltransferase 1

Cat.:

P15261Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Protein arginine N-methyltransferase 1

Cat.:

P15261Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Protein arginine N-methyltransferase 1

Protein for Mouse Protein arginine N-methyltransferase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable."
Pawlak M.R. , Scherer C.A. , Chen J. , Roshon M.J. , Ruley H.E.
Mol. Cell. Biol.20:4859-4869(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
3.

"Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes."
Mowen K.A. , Schurter B.T. , Fathman J.W. , David M. , Glimcher L.H.
Mol. Cell15:559-571(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NFATC2IP
4.

"Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases."
van Dijk T.B. , Gillemans N. , Stein C. , Fanis P. , Demmers J. , van de Corput M. , Essers J. , Grosveld F. , Bauer U.M. , Philipsen S.
Mol. Cell. Biol.30:260-272(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH CHTOP;SUBCELLULAR LOCATION
tissue: Erythroblast.
5.

"Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation."
Fanis P. , Gillemans N. , Aghajanirefah A. , Pourfarzad F. , Demmers J. , Esteghamat F. , Vadlamudi R.K. , Grosveld F. , Philipsen S. , van Dijk T.B.
Mol. Cell. Proteomics11:1263-1273(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CHTOP;SUBCELLULAR LOCATION
6.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-134;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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